Allylamine → HCID 20718746, compound

Participants

Reaction Conditions

Reaction Steps

In 1 ml of 1,3-dimethyl-2-imidazolidinone was dissolved 300 mg (1.18 mmol) of 4-allylamino-2,6-dichloroquinazoline, and after 110 mg (1.87 mmol) of allylamine was added to the resulting solution, the mixture was stirred in a sealed tube at 100° C. for 10 hours. A saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 283 mg (yield: 87.3%) of the title compound.

Provenance & Evidence