Allylamine → HCID 70162617, compound

Participants

Reaction Steps

In a sealed tube were stirred 100 mg (0.40 mmol) of 4-allylamino-2-chloro-6-methylaminoquinazoline and 761 mg (13.33 mmol) of allylamine at 140° C. for 22 hours. A saturated aqueous sodium hydrogen carbonate was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 100 mg (yield: 92.4%) of a free base compound of the title compound.

Provenance & Evidence