Propylamine → HCID 18326550, compound

Participants

Reaction Steps

A mixture of 250 mg (0.95 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 719 mg (12.16 mmol) of propylamine were stirred at room temperature for 2.5 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 211 mg (yield: 77.7%) of the title compound.

Provenance & Evidence