Water → HCID 18326560, compound

Participants

Reaction Steps

In 0.5 ml of acetonitrile were dissolved 250 mg (0.95 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 740 mg (8.49 mmol) of neopentylamine, and the resulting solution was stirred at room temperature for 5 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 215 mg (yield: 72.2%) of the title compound.

Provenance & Evidence