Diallylamine → HCID 18326485, compound

HRID 1250567Notes

Reaction equation

HRID 1250567 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([Cl:18])[C:13]=2[N+]([O-])=O)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[CH2:20]([NH:23][CH2:24][CH:25]=[CH2:26])[CH:21]=[CH2:22]>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([Cl:18])[CH:13]=2)[N:8]=[C:7]([N:23]([CH2:24][CH:25]=[CH2:26])[CH2:20][CH:21]=[CH2:22])[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 31279DiallylamineHCID 18326545HCID 18326545, compound

Product 1

HCID 18326485HCID 18326485, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a sealed tube were stirred 268 mg (1.06 mmol) of 4-allylamino-2,6-dichloronitroquinazoline and 787 mg (8.10 mmol) of diallylamine at 120° C. for 3 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by silica gel column to give 284 mg (yield: 85.1%) of the title compound.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by silica gel column

Sources & evidence

ORD record
ord-81b1d59559934edb8bf85fdb63bdca94
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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