反应详情

A mixture of 250 mg (0.95 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 796 mg (15.52 mmol) of a 70% aqueous ethylamine solution was stirred at room temperature for 3 hours. Water. was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 234 mg (yield: 90.6%) of the title compound.

1. additionwas added to the reaction mixture
2. extractionfollowed by extraction with ethyl acetate
3. washwashing with brine
4. dry with materialdrying over anhydrous sodium sulfate
5. distillationAfter the solvent was distilled off
6. customthe residue was purified by a silica gel column