Ethylenediamine → HCID 18326514, compound

Participants

Reaction Steps

A mixture of 230 mg (0.87 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 899 mg (14.96 mmol) of ethylenediamine was stirred at room temperature for 2 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 200 mg (yield: 79.9%) of the title compound.

Provenance & Evidence