1-Heptanamine → HCID 18326478, compound

HRID 1250586Notes

Reaction equation

HRID 1250586 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[CH2:19]([NH2:26])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7]([NH:26][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 81271-HeptanamineHCID 183264874-Allylamino-2-chloro-6-nitroquinazoline

Product 1

HCID 18326478HCID 18326478, compoundYield 87.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 200 mg (0.76 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 1.55 g (13.49 mmol) of heptylamine was stirred at room temperature for 2 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate, washing brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 228 mg (87.8%) of the title compound.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

Sources & evidence

ORD record
ord-eb60dd588a824292aad5f1dd6c2e416d
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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