1-Aminopiperidine → HCID 18326554, compound

HRID 1250587Notes

Reaction equation

HRID 1250587 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[NH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7]([NH:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 166581-AminopiperidineHCID 183264874-Allylamino-2-chloro-6-nitroquinazoline

Product 1

HCID 18326554HCID 18326554, compoundYield 40.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 200 mg (0.76 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline and 1.86 g (18.53 mmol) of 1-aminopiperidine was stirred at room temperature for 2 hours. Water was added to the reaction solution followed by extraction with ethyl acetate, washing brine, and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 100 mg (40.3%) of the title compound.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

Sources & evidence

ORD record
ord-c1ff8620a3844e26b3ad5f9ac1bd6443
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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