Acetic Anhydride → 4-Acetylamino-2-allylamino-6-nitroquinazoline

Participants

Reaction Steps

300 mg (1.22 mmol) of 2-allylamino-4-amino-6-nitroquinazoline was dissolved in 5 ml of THF, and then 5.0 g (29.38 mmol) of acetic anhydride and 30 mg (0.37 mmol) of sodium acetate were added thereto, followed by stirring at room temperature for 12 hours. The reaction solution was neutralized with a 1 N aqueous sodium hydroxide solution. Crystals thus precipitated were filtered, followed by washing with water and drying to give 150 mg (42.7%) of the title compound.

Provenance & Evidence