Allylamine → 4-(1-Adamantylamino)-2-allylamino-6-nitroquinazoline

HRID 1250603노트

반응식

HRID 1250603 반응식
[C:1]12([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N+:22]([O-:24])=[O:23])[CH:20]=4)[N:15]=[C:14](Cl)[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH2:26]([NH2:29])[CH:27]=[CH2:28]>O>[C:1]12([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N+:22]([O-:24])=[O:23])[CH:20]=4)[N:15]=[C:14]([NH:29][CH2:26][CH:27]=[CH2:28])[N:13]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

4

반응물 2

HCID 7853AllylamineHCID 183264334-(1-Adamantylamino)-2-chloro-6-nitroquinazoline

생성물 1

HCID 183265204-(1-Adamantylamino)-2-allylamino-6-nitroquinazoline수율 88.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 82 mg (0.25 mmol) of 4-(1-adamantylamino)-2-chloro-6-nitroquinazoline was added 1.00 ml (13.33 mmol) of allylamine, and the resulting mixture was stirred at room temperature overnight. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 77 mg (88.7%) of the title compound.

후처리

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

출처 및 근거

ORD 기록
ord-c054063fe66648fda753fc91b724e657
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06339089B2

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