反应详情

To 82 mg (0.25 mmol) of 4-(1-adamantylamino)-2-chloro-6-nitroquinazoline was added 1.00 ml (13.33 mmol) of allylamine, and the resulting mixture was stirred at room temperature overnight. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 77 mg (88.7%) of the title compound.

1. extractionfollowed by extraction with ethyl acetate
2. washwashing with brine
3. dry with materialdrying over anhydrous sodium sulfate
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by a silica gel column