Water → 4-Allylamino-6-nitro-2-(2-pyridylmethylamino)quinazoline

Participants

Reaction Steps

150 mg (0.57 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline was dissolved in 10 ml of acetonitrile, and then 165 mg (1.14 mmol) of 2-pyridylmethylamine hydrochloride and 0.40 ml (2.85 mmol) of triethylamine were added thereto, followed by heating under reflux overnight. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 180 mg (93.9%) of the title compound.

Provenance & Evidence