Thionyl Chloride → HCID 18326463, compound

Participants

Reaction Steps

To a solution of 50 mg (0.173 mmol) of 4-allylamino-2-(2-hydroxyethylamino)-6-nitroquinazoline in dichloromethane was added 1.63 g (13.7 mmol) of thionyl chloride, and then the resulting mixture was stirred at room temperature for 4 hours. After the mixture was subjected to heating under reflux for further one hour, the solvent was distilled off under reduced pressure. The residue was purified by a silica gel chromatography to give 25 mg (yield: 46.8%) of the title compound.

Provenance & Evidence