Water → 2-Chloro-7-methyl-4-neopentylaminothieno[3,2-d]pyrimidine

HRID 1250617ノート

反応式

HRID 1250617 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1.[CH2:13]([NH2:18])[C:14]([CH3:17])([CH3:16])[CH3:15].O>CN(C=O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:18][CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15])[C:5]2[S:10][CH:9]=[C:8]([CH3:11])[C:6]=2[N:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 79882NeopentylamineHCID 71470642,4-Dichloro-7-methylthieno(3,2-d)pyrimidine

生成物 1

HCID 183264882-Chloro-7-methyl-4-neopentylaminothieno[3,2-d]pyrimidine収率 96.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In 3 ml of DMF was dissolved 300 mg (1.4 mmol) of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine, and after 179 mg (2.1 mmol) of neopentylamine was added to the resulting solution, the mixture was stirred for 3 hours. Water was added to the reaction mixture, and crystals thus precipitated were filtered to give 355 mg (yield: 96.1%) of the title compound.

後処理

  1. customthus precipitated
  2. filtrationwere filtered

出典と根拠

ORDレコード
ord-112530ea9a734afe92f00877dace037a
出典データセット
uspto-grants-2002_01
特許番号
US06339089B2

反応ノート

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