Allylamine → HCID 18326563, compound

Participants

Reaction Steps

150 mg (0.62 mmol) of 2-chloro-7-methyl-4-(2,2-dimethylhydrazino)thieno[3,2-d]pyrimidine and 564 mg (9.89 mmol) of allylamine were heated in a sealed tube at 160° C. for 16 hours. After completion of the reaction, the reaction mixture was allowed to resume room temperature, followed by adding a saturated aqueous sodium hydrogen carbonate solution thereto and extraction with ethyl acetate (50 ml×2). After the organic layer was washed with brine and dried over anhydrous sodium sulfate, the solvent was distilled off. The residue was purified by a silica gel chromatography (eluent: ethyl acetate-hexane=1/2) to give 151 mg (yield: 92.6%) of the title compound.

Provenance & Evidence