Triethylamine → HCID 18326515, compound

Participants

Reaction Steps

To a solution of 150 mg (0.68 mmol) of 2-allylamino-4-amino-7-methylthieno[3,2-d]pyrimidine and 83 mg (0.82 mmol) of triethylamine in dichloromethane was added 82 mg (0.68 mmol) of pivaloyl chloride, followed by heating under reflux for 1 hour. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was purified by a silica gel chromatography (eluent: ethyl acetate-hexane=1/4] to give 90 mg (yield: 43.5%) of the title compound.

Provenance & Evidence