Tert-Butylamine → HCID 18326431, compound

Participants

Reaction Steps

To a solution of 306 mg (1.4 mmol) of di-t-butyldicarbonate in acetonitrile was added 122 mg (1.0 mmol) of N,N-dimethylaminopiridine at room temperature, followed by stirring for 20 minutes. 220 mg (1.0 mmol) of 2-allylamino-4-amino-7-methylthieno[3,2-d]pyrimidine was added to the reaction solution, followed by stirring at room temperature for 2 hours. Further, after 102 mg (1.4 mmol) of t-butylamine was added to the mixture, the reaction mixture was subjected to heating under reflux for 16 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was purified by a silica gel chromatography (eluent: ethyl acetate-hexane=1/23 to give 161 mg (yield: 50.5%) of the title compound.

Provenance & Evidence