Allylamine → HCID 18326466, compound

Participants

Reaction Steps

189 mg (0.71 mmol) of 4-allylamino-2-chloro-7-propylthieno[3,2-d]pyrimidine and 644 mg (11.3 mmol) of allylamine were heated in a sealed tube at 140° C. for 16 hours. After completion of the reaction, the reaction mixture was allowed to resume room temperature, followed by adding a saturated aqueous sodium hydrogen carbonate solution thereto and extraction with ethyl acetate (50 ml×2). After the organic layer was washed with brine and dried over anhydrous sodium sulfate, the solvent was distilled off. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/4) to give 116 mg (yield: 56.9%) of the title compound.

Provenance & Evidence