Allylamine → HCID 15908141, compound

Participants

Reaction Steps

50 mg (0.21 mmol) of 2-chloro-4-methylamino-7-propylthieno[3,2-d]pyrimidine and 189 mg (3.31 mmol) of allylamine were heated in a sealed tube at 160° C. for 16 hours. After completion of the reaction, the reaction mixture was allowed to resume room temperature, followed by adding a saturated aqueous sodium hydrogen carbonate solution thereto and extraction with ethyl acetate (50 ml×2). After the organic layer was washed with brine and dried over anhydrous sodium sulfate, the solvent was distilled off. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/4) to give 37 mg (yield: 68.5%) of the title compound.

Provenance & Evidence