反应详情

温度

80 °C

To 250 ml of a solution of 7.31 g (52.2 mmol) of thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione in acetic acid was added 25.0 g (156 mmol) of bromine at room temperature, followed by heating at 80° C. for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. Ice water was added to the residue, followed by filtering out crystals thus precipitated to give 7.24 g (yield: 56.2%) of the title compound.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off under reduced pressure
3. additionIce water was added to the residue
4. filtrationby filtering out crystals
5. customthus precipitated