Allylamine → 2,4-Diallylamino-7-bromothieno[3,2-d]pyrimidine

Participants

Reaction Steps

305 mg (1.0 mmol) of 4-allylamino-7-bromo-2-chlorothieno[3,2-d]pyrimidine and 914 mg (16.0 mmol) of allylamine were heated in a sealed tube at 160° C. for 16 hours. After completion of the reaction, the reaction mixture was allowed to resume room temperature, followed by adding a saturated aqueous sodium hydrogen carbonate solution thereto and extraction with ethyl acetate (50 ml×2). After the organic layer was washed with brine and dried over anhydrous sodium sulfate, the solvent was distilled off. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/4) to give 304 mg (yield: 93.3%) of the title compound.

Provenance & Evidence