Sodium Hydroxide → HCID 18326593, compound

Participants

Reaction Conditions

Reaction Steps

(−)-4-(3,4-Difluorophenyl)-3,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester (650 mg, 2.19 mmol) was dissolved in methanol (10 ml), treated with 2.5N sodium hydroxide (10 ml), and warmed to 500° C. for 8hr. The solvent was removed in vacuo, the remaining aqueous phase treated with 10% KHSO4 (aq), and extracted with ethyl acetate (3X). The extracts were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated to dryness in vacuo to give a crude oil. Crystallization from diethyl ether gave the product as a white solid [αD]=−128°, c=0.20 MeOH).

Provenance & Evidence