2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate → 2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate hydrochloride

HRID 1250765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1250765
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Komponenten

4

Edukt 2

HCID 98074162-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 185202882-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4N Hydrochloric acid/ethyl acetate solution (0.11 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate (0.20 g) in ethyl acetate (2 ml) while being cooled with ice. After being stirred for 20 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (0.19 g) as white solid.

Aufarbeitung

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8505cb392572469489ba6f1326793bbc
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06339154B1

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