Dihydrocoumarin → HCID 18520251, compound

HRID 1250775Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:14]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][C:15]1=[O:16]>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:15](=[O:16])[CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:24]=2[OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 660Dihydrocoumarin

HCID 759941-Benzylpiperazine

Product 1

HCID 18520251HCID 18520251, compoundYield 108.9%

Conditions

Temperature: 90 °C

Procedure

1-Benzylpiperazine (2.38 g) was added to 3,4-dihydrocoumarine (2.00 g) and stirred for 3 hours at 90° C., thereby yielding the entitled compound (4.77 g) as pale brown syrup.

Sources & evidence

ORD record: ord-a3cf3e71a5ae4e1fb41547bf6a248f06
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06339154B1

Reaction notes

Loading…