HCID 57011895, compound → HCID 9936588, compound

HRID 1250863Notes

Reaction equation

HRID 1250863 reaction equation
C([O:5][C:6](=[O:39])[C@@H:7]([NH:28][S:29]([C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]2[NH:22][CH2:23][CH2:24][CH2:25][N:26]=2)=[CH:11][CH:10]=1)(C)(C)C>FC(F)(F)C(O)=O.O>[Cl:38][C:35]1[CH:36]=[CH:37][C:32]([S:29]([NH:28][C@@H:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][C:19](=[O:27])[NH:20][C:21]3[NH:26][CH2:25][CH2:24][CH2:23][N:22]=3)=[CH:11][CH:10]=2)[C:6]([OH:39])=[O:5])(=[O:30])=[O:31])=[CH:33][CH:34]=1

Participants

3

Reactant 1

HCID 57011895HCID 57011895, compound

Product 1

HCID 9936588HCID 9936588, compound

Reagents, catalysts & solvents 1

HCID 22392675Trifluoroacetic acid waterSolvent

Procedure

35.7 mg of (2S)-2-(4-chlorobenzenesulfonylamino)-3-{4-[3-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)-propoxy]-phenyl}-propionic acid tert-butyl ester were dissolved in trifluoroacetic acid/water (95/5) and stirred for 2 hours. The solvent was removed in vacuo. The residue was dissolved in acetic acid/water and lyophilized. Yield 20.2 mg. MS (ES+): m/e=523.1 (M)+.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in acetic acid/water

Sources & evidence

ORD record
ord-77a3ddd81a604d21b5eac530e2a09718
Source dataset
uspto-grants-2002_01
Patent number
US06340679B1

Reaction notes

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