反应详情

A mixture of 5-chloro-2-methylaniline (12.3 g) and the N-ethyl-1-amino-3-bromopropane hydrobromide salt of Example 3, Step C (8.6 g) was heated at 100° C. under nitrogen for 20 minutes. After cooling, a solid mass formed which was partitioned between dichloromethane and 1 N sodium hydroxide. The organic phase was washed with brine, dried over anhydrous potassium carbonate, filtered and concentrated in vacuo to give a brown oil. The crude material was dissolved in dichloromethane and absorbed onto a column of Merck-60 flash silica gel. Elution with a solvent gradient (from 100% dichloromethane to 9:1 dichloromethane-methanol containing 0.2% ammonium hydroxide) provided the title compound (7.3 g, 92.8%) as a brown oil, which was used as such in the next step.

1. temperatureAfter cooling
2. customa solid mass formed which
3. customwas partitioned between dichloromethane and 1 N sodium hydroxide
4. washThe organic phase was washed with brine
5. dry with materialdried over anhydrous potassium carbonate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto give a brown oil
9. customabsorbed onto a column of Merck-60 flash silica gel
10. washElution with a solvent gradient (from 100% dichloromethane to 9:1 dichloromethane-methanol containing 0.2% ammonium hydroxide)