Hydrochloric Acid → HCID 86757736, compound

Participants

Reaction Steps

(E)-(5-mthyl-1, 2, 3-thiadiazol-4-yl) phenylmethanone oxime (0.30 g, 1.4 mmol) was dissolved in acetone (20 ml), potassium carbonate (0.32 g, 2.0 mmol) and hydrochloride of 2-picolylchloride (0.34 g, 2.0 mmol) were added and heated for 3 days with refluxing. After concentrating the thus reacted solution, the residue was extracted with ethylacetate, and after washing with water, the residue was dried with magnesium sulfate. The solvent was removed by distillation, the residue was refined in a column chromatography, and yielded (E)-(5-mthyl-1, 2, 3-thiadiazol-4-yl)phenyl-methanone O-(2-pyridyl) methyloxime.

Provenance & Evidence