Quinoline-3-carboxylic acid → HCID 10141381, compound

HRID 1250927Notes

Reaction equation

HRID 1250927 reaction equation
[OH:1][NH:2][C:3](=[O:27])[CH:4]([S:14]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]#[C:25][CH3:26])=[CH:18][CH:17]=1)=[O:15])[CH2:5][CH2:6][CH2:7][CH2:8][N:9](N)[C:10](=[O:12])[CH3:11].[N:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=C(C(O)=O)[CH:29]=1>>[CH2:23]([O:22][C:19]1[CH:20]=[CH:21][C:16]([S:14]([CH:4]([C:3](=[O:27])[NH:2][OH:1])[CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10]([C:11]2[CH:29]=[N:28][C:37]3[C:32]([CH:31]=2)=[CH:33][CH:34]=[CH:35][CH:36]=3)=[O:12])=[O:15])=[CH:17][CH:18]=1)[C:24]#[C:25][CH3:26]

Participants

3

Reactant 2

HCID 80971Quinoline-3-carboxylic acidHCID 86586092HCID 86586092, compound

Product 1

HCID 10141381HCID 10141381, compound

Procedure

6-(Amino-acetylamino)-2-(4but-2-ynoxy-benzenesulfinyl)-hexanoic acid hydroxyamide resin (0.33 g, 1.1 meq/g) prepared in step B was acylated with 3-quinolinecarboxylic acid (1.2 g, 4.0 eq) according to the procedure in Example 13, Step E to give quinoline-3-carboxylic acid [5-(4-but-2-ynyloxy-benzenesulfinyl)-5-hydroxycarbamoyl-pentyl]-amide resin.

Sources & evidence

ORD record
ord-ca0b693a48f24f3bb0c9e71360d92756
Source dataset
uspto-grants-2002_01
Patent number
US06340691B1

Reaction notes

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