1-Bromo-2-butyne → HCID 11152913, compound

Participants

Reaction Steps

Ethyl {[4-(2-butynyloxy)phenyl]sulfanyl}(4-methoxyphenyl)acetate was prepared according to the general method as outlined in example 1 (step 1), starting from ethyl [(4-hydroxyphenyl)sulfanyl](4-methoxyphenyl) acetate (15.82 g, 49.7 mmol) and 4-bromo-2-butyne (4.79 ml, 54.7 mmol); 17.66 g yellow oil. Yield 96%; MS(EI): 370.1 (M+H)+{[4-(2-butynyloxy)phenyl]sulfanyl}(4-methoxyphenyl) acetic acid was prepared according to the general method as outlined in example 1 (step 5), (the hydrolysis was carried out at room temperature for 24 hrs) starting from ethyl {[4-(2-butynyloxy)phenyl]sulfanyl}(4-methoxyphenyl)acetate (10 g, 27 mmol); 5.78 g yellow oil. Yield 63%; MS: 341.2 (M−H)−

Provenance & Evidence