Sulfuric Acid → HCID 18325123, compound

Participants

Reaction Steps

5-Amino-1,3-benzodioxole-4-yl 1,3-benzodioxole-4-yl ketone (2.7 g) and 2-ketobutyric acid methyl ester (1.9 g) were dissolved in acetic acid (30 ml), followed by addition of sulfuric acid (0.3 ml). The mixture was refluxed for 1.5 hours and then concentrated under reduced pressure. Water was added to the residue, followed by extraction with ethyl acetate. The extract was washed with aqueous sodium hydrogen carbonate solution and water successively, dried over magnesium sulfate and concentrated under reduced pressure to yield the title compound as yellow crystals (2.6 g).

Provenance & Evidence