Hydrochloric Acid → HCID 18325066, compound

Participants

Reaction Steps

2.5% aqueous NaoH solution (20 ml) was added to a solution of 9-(1,3-benzodioxole-5-yl)-8-methyl-1,3-dioxolo[4,5-f]quinoline-7-carboxylic acid methyl ester in methanol (20 ml). The mixture was refluxed for one hour. 1N HCl was added to the reaction mixture to make it slightly acidic (pH 5), followed by extraction with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to yield the title compound as yellow crystals (252 mg). Some portions of the compound were recrystalized from THF to be used for elemental and instrumental analysis.

Provenance & Evidence