Water → HCID 18325115, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (180 mg) in THF (15 ml), ethyl 3-ethoxycarbonylmethyl-4-(4-fluorophenyl)-6-methoxyquinoline-2-carboxylate (1.0 g) was added, followed by stirring at 0° C. for 30 minutes. Water was added to the reaction mixture to stop the reaction; after the insoluble substances were filtered off, the product was extracted with ethyl acetate. After being washed with water, the extract was dried over magnesium sulfate and concentrated under reduced pressure to yield a crude crystal (1 g) of the title compound. The crude crystal obtained was used for the next reaction without further purification.

Provenance & Evidence