HCID 18325113, compound → HCID 18325095, compound

HRID 1250951Notes

Reaction equation

HRID 1250951 reaction equation
[N:1]1([C:7]2[C:16]3[CH:15]=[C:14]4[O:17][CH2:18][O:19][C:13]4=[CH:12][C:11]=3[N:10]=[C:9]([C:20]([O:22]CC)=O)[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][NH2:26].CO>>[CH3:25][NH:26][C:20]([C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:16]2[CH:15]=[C:14]3[O:17][CH2:18][O:19][C:13]3=[CH:12][C:11]=2[N:10]=1)=[O:22]

Participants

3

Reactant 2

HCID 18325113HCID 18325113, compoundHCID 57454252Monomethylamine methanol

Product 1

HCID 18325095HCID 18325095, compound

Procedure

After a mixture of ethyl 8-(1-piperidinyl)-1,3-dioxolo[4,5-g]quinoline-6-carboxylate as obtained in Reference Example 31 (60 mg) and a 40% methylamine-methanol solution (5 ml) was stirred at room temperature for 3 hours, the solvent was distilled off under reduced pressure to yield the title compound as a colorless powder (33.6 mg).

Workup

  1. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-fae5feebeb2b4174b8da6d471d86f655
Source dataset
uspto-grants-2002_01
Patent number
US06340704B1

Reaction notes

Loading…