Phosphorodichloridous acid, 2-cyanoethyl ester → Phosphonochloridous acid, P-4-morpholinyl-, 2-cyanoethyl ester

Participants

Reaction Steps

To a solution of 2-Cyanoethyldichlorophosphite (3.0 g, 17.5 mmol, 2.2 mL) in CH2Cl2 (45 mL) was added dropwise 4-(trimethylsilyl)morpholine (3.1 mL, 2.8 g, 17.5 mmol) at 0° C. The resulting mixture was stirred for 2 h at room temperature. The solvent was removed under reduced pressure to give a pale yellow oil (3.87 g, 86%) as a product.

Provenance & Evidence