Water → 6-(1fluoroethyl)-4-pyrimidone
Reaction equation
CO.C[O-].[Na+].C(O)(=O)C.[CH:10]([NH2:12])=[NH:11].S(=O)(=O)(O)O.O.[F:19][CH:20]([CH3:29])[C:21](=O)[CH2:22][C:23](OCC)=[O:24]>CO>[F:19][CH:20]([C:21]1[N:12]=[CH:10][NH:11][C:23](=[O:24])[CH:22]=1)[CH3:29]Participants
Conditions
- Temperature
- 50 °C
Procedure
To a solution in which 24.3 g of ethyl 4-fluoro-3-oxopentanoate had been dissolved in 330 ml of methanol were added 72.3 g of a 28 % sodium methoxide methanol solution and 15.6 g of formarnidine acetate, and the mixture was stirred at 50° C. for 3 hours. To the mixture was further added 7.81 g of formamidine acetate and after stirring the mixture at 50° C. for 4 hours, the mixture was cooled to 10° C. or lower. After cooling, 18.8 g of conc. sulfuric acid and 13.5 g of water were added to the reaction mixture. After stirring the mixture at 50° C. for 15 minutes, insolubles were removed by filtration and the filtrate was quantitated by the liquid chromatography internal standard method. As a result, 18.0 g of 6-(1-fluoroethyl)-4-pyrimidone was formed (yield: 84.6%).
Workup
- stirringafter stirring the mixture at 50° C. for 4 hours
- temperaturethe mixture was cooled to 10° C.
- temperatureAfter cooling
- stirringAfter stirring the mixture at 50° C. for 15 minutes
- custominsolubles were removed by filtration
Sources & evidence
- ORD record
- ord-e53c2d00ed16414f92d131a631e199ad
- Source dataset
- uspto-grants-2002_01
- Patent number
- US06340757B1
Reaction notes
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