Acetic Acid → HCID 178526512, compound

HRID 1251003Notes

Reaction equation

HRID 1251003 reaction equation
[OH:1][C:2]1[N:3]=[C:4]([O:28]C)[C:5]2[CH:15]([C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)[C:14]3[C:9](=[N:10][C:11]([OH:27])=[N:12][C:13]=3[O:25]C)[O:8][C:6]=2[N:7]=1.C(O)(=O)C.C(OC(=O)C)(=O)C>S(=O)(=O)(O)O.O>[OH:1][C:2]1[N:3]=[C:4]([OH:28])[C:5]2[CH:15]([C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=3)[C:14]3[C:9](=[N:10][C:11]([OH:27])=[N:12][C:13]=3[OH:25])[O:8][C:6]=2[N:7]=1

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 178494284HCID 178494284, compound

Product 1

HCID 178526512HCID 178526512, compoundYield 25%

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 962WaterSolvent

Procedure

To a mixture of 3.4 mmol of 2,8-dihydroxy4,6-dimethoxy-5-(p-nitrophenyl)-5H-pyrano[2,3-d:6,5-d′]dipyrimidine, 10 ml of acetic acid, and 10 ml of acetic anhydride there are added 8-12 drops of concentrated sulfuric acid. The mixture is stirred while being boiled for 8-10 hours, and then poured into 150 ml of cold water and left over night. Separation and purification of the resulting substances is as described above. Yield 25-30%

Workup

  1. waitleft over night
  2. customSeparation and purification of the resulting substances

Sources & evidence

ORD record
ord-a4c9f423fc544940a8b31f90bf45ab0f
Source dataset
uspto-grants-2002_01
Patent number
US06340755B1

Reaction notes

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