Methanol → Methyl 1,2,3,4-tetrahydro-6-methyl-2,3-dioxo-5-quinoxalinecarboxylate

Participants

Reaction Steps

A solution of 2,3-diamino-6-methylbenzoic acid, methyl ester (compound 6) (1.14 g, 6.35 mmol) and dimethyl oxalate (3.34 g, 28.5 mmol) in MeOH (30 mL) was refluxed for 6 days. Upon cooling to room temperature, the precipitated product was collected and washed with a small amount of MeOH to give 1.02 g (69%).

Provenance & Evidence