Sodium Hydroxide → (Z)-2-[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetic acid

Participants

Reaction Steps

A 1N aqueous solution of sodium hydroxide (5 ml) was added to a solution of 1,080 mg of methyl (Z)-[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetate in 30 ml of methanol, followed by stirring at room temperature for 18 hours. After evaporating the reaction solution, 20 ml of water and 10 ml of 1N hydrochloric acid were added to the residue, and the resulting precipitate was collected by filtration and washed with water to give 1,000 mg of (Z)-[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetic acid as a colorless powder.

Provenance & Evidence