Sodium Hydroxide → HCID 15552384, compound

Participants

Reaction Steps

To a solution of 150 mg of ethyl (Z)-(1-{[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetyl}-4-piperidyl)acetate in 5 ml of ethanol was added 1 ml of a 1N aqueous solution of sodium hydroxide, followed by stirring at room temperature for 18 hours. After evaporating off the reaction solution, 1 ml of 1N hydrochloric acid was added to the residue, and the resulting precipitate was collected by filtration and washed with water to give 120 mg of (Z)-(1-{[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetyl}-4-piperidyl)acetic acid as a colorless powder.

Provenance & Evidence