Triethylamine → HCID 86757743, compound

Participants

Reaction Steps

To a solution of 200 mg of (Z)-1-{[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetyl}piperidin-4-one in a mixture of 6 ml of dichloromethane and 3 ml of methanol were added 29 mg of hydroxylamine monohydrochloride and 59 μl of triethylamine, followed by stirring at room temperature for 22 hours. After evaporating the solvent, the residue was purified by silica gel column chromatography (eluting with chloroform-methanol), followed by crystallizing from diethyl ether to give 61 mg of (Z)-4,4-difluoro-5-{2-[4-(hydroxyimino)piperidino]-2-oxo-ethylidene}-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepine as a colorless powder.

Provenance & Evidence