Acetic Anhydride → HCID 86757744, compound

Participants

Reaction Steps

A solution of 51 mg of (Z)-4,4-difluoro-5-{2-[4-(hydroxyimino)piperidino]-2-oxoethylidene}-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepine in a mixture of 800 μl of acetic anhydride and 800 μl of pyridine was stirred at room temperature for eight hours. The solvent was evaporated, the residue was dissolved in ethyl acetate, and the solution was washed with 1N hydrochloric acid and a saturated aqueous solution of NaCl. After drying over anhydrous magnesium sulfate, the solvent was evaporated therefrom. The residue was purified by silica gel column chromatography (eluting with chloroform) to give 36 mg of (Z)-4,4-difluoro-5-{2-[4-(acetoxyimino)piperidino]-2-oxoethylidene}-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepine as a colorless solid.

Provenance & Evidence