Potassium Carbonate → HCID 70161506, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 240 mg of ethyl (Z)-[(1-{[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetyl}-4-piperidyl)-(trifluoroacetyl)amino]acetate in 5 ml of ethanol was added a solution of 100 mg of potassium carbonate in 4 ml of water, and the mixture was stirred at 40° C. for 18 hours. After evaporation of the solvent, 1N hydrochloric acid was added to the residue, and the mixture was washed with ethyl acetate. The aqueous layer was neutralized and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of NaCl and dried over anhydrous magnesium sulfate, and the solvent was evaporated therefrom. The resulting residue was crystallized from diethyl ether to give 40 mg of (Z)-[(1-{[4,4-difluoro-1-(4-methyl-2-phenylthiazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene]acetyl}-4-piperidyl)amino]acetic acid as a pale yellow powder.

Provenance & Evidence