Ammonia → 7-(4-Methoxyphenyl)-1,6-naphthyridin-5(6H)-one

Participants

Reaction Conditions

Reaction Steps

2-[2-(4-Methoxyphenyl)-2-hydroxyethenyl]-N-methylnicotinamide (2.509 g) was added to a 29% aqueous solution of ammonia (100 ml) and dioxane (50 ml), which was then heated in a sealed tube at 170° C. overnight. After cooling as it was, the resulting insoluble matters were collected by filtration, to give the title compound as a dark green solid (1.694 g, yield; 73%).

Provenance & Evidence