反应详情

To a solution of the resulting 1-(4-ethylpiperazin-1-yl)-3-phenacylisoquinoline (0.92 g) in methanol (30 ml) was added sodium borohydride (0.12 g) at room temperature. One hr later, the reaction mixture was concentrated. The resulting residue was partitioned between ethyl acetate and water, and extracted with ethyl acetate. The resulting organic layer was washed with water and brine, and dried over magnesium sulfate. The solvent was removed, to give the title compound (0.81 g) as a pale yellow oil.

1. concentrationOne hr later, the reaction mixture was concentrated
2. customThe resulting residue was partitioned between ethyl acetate and water
3. extractionextracted with ethyl acetate
4. washThe resulting organic layer was washed with water and brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed