HRID1251333

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[N+]1(CC(NC(=O)Nc2cc(OC)c(OC)c(OC)c2)C(C)C)CCC(Cc2ccc(Cl)c(Cl)c2)CC1.[I-]

HCID23503328

未命名化合物

PRODUCTS

生成物

结构：CC[N+]1(CC(NC(=O)Nc2cc(OC)c(OC)c(OC)c2)C(C)C)CCC(Cc2ccc(Cl)c(Cl)c2)CC1.[Cl-]

HCID18680423

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of 4-(3,4-dichlorobenzyl)-1-ethyl-1-{3-methyl-2-[3-(3,4,5-trimethoxy-phenyl)ureido]butyl}piperidinium iodide (0.2 g) in methanol (5 ml) was slowly passed through a column of Dowex 1x8-50 ion exchange resin (3 g). The eluted product was concentrated in vacuo to give 4-(3,4-dichlorobenzyl)-1-ethyl-1-{3-methyl-2-[3-(3,4,5-trimethoxyphenyl)ureido]butyl}piperidinium chloride.

WORKUP

后处理

concentrationThe eluted product was concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d066ce0fed3e4604a466b99d2ebbb920
来源数据集: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06342509B1
来源说明: uspto-grants-2002_01

反应 SMILES

[I-].[Cl:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:6][CH:7]1[CH2:12][CH2:11][N+:10]([CH2:34][CH3:35])([CH2:13][CH:14]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=2)=[O:20])[CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:8]1>CO>[Cl-:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:6][CH:7]1[CH2:8][CH2:9][N+:10]([CH2:34][CH3:35])([CH2:13][CH:14]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=2)=[O:20])[CH:15]([CH3:17])[CH3:16])[CH2:11][CH2:12]1