Sodium Hydroxide → HCID 18172495, compound

HRID 1251342Notes

Reaction equation

HRID 1251342 reaction equation
[CH2:1]([N:4]1[C:9](=[O:10])[C:8]([C:11]([O:13]CC)=[O:12])=[CH:7][N:6]=[CH:5]1)[CH:2]=[CH2:3].[OH-].[Na+]>CO.O>[CH2:1]([N:4]1[C:9](=[O:10])[C:8]([C:11]([OH:13])=[O:12])=[CH:7][N:6]=[CH:5]1)[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 18172515HCID 18172515, compound

Product 1

HCID 18172495HCID 18172495, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To the compound of Example 21 (5.00 g, 0.024 mole), suspended in methanol (25 mL) and cooled in an ice bath, 1.0N NaOH (29 mL, 0.029 mole) is added dropwise rapidly with stirring. After 16 hours, the solvent is reduced under vacuum, residue diluted with water (50 mL), and washed with ethyl acetate (2×15 mL). The aqueous layer is acidified with 2.0N HCl to pH 1, extracted with ethyl acetate (3×50 mL). The combined organic extracts are washed with water, then brine (twice). The solvent is removed in vacuo to afford the title compound.

Workup

  1. temperaturecooled in an ice bath
  2. washwashed with ethyl acetate (2×15 mL)
  3. extractionextracted with ethyl acetate (3×50 mL)
  4. washThe combined organic extracts are washed with water
  5. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-f659649e604f408390c4d7292b81ffe7
Source dataset
uspto-grants-2002_01
Patent number
US06342504B1

Reaction notes

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