tert-Butyl 3-nitro-2-oxo-1(2H)-pyridineacetate → 3-Amino-1-(tert-butoxycarbonylmethyl)-2-pyridinone

Participants

Reaction Steps

The compound of Example 137 (54 g, 0.213 mole) and 880 ml of methanol and 5 g of 10% palladium on carbon were stirred under 1 Atm of hydrogen for 24 hours. The reaction mixture was filtered and the carbon was washed with 200 mL of dichloromethane. The organic layer was evaporated to yield 47.08 g (98.5 %) of the title compound as a brown solid.

Provenance & Evidence