反应详情

4-(3-methyl-piperidino)-tetrahydro-4H-thiopyran-4-carbonitrile (2 g, 8.9 mmoles) dissolved in 50 ml of anhydrous ether is introduced dropwise into a 2-benzothiophenylmagnesium bromide (44.7 mmoles) solution. Ether is heated under reflux for 20 hours. After the usual treatment, a brown oil is obtained (1.7 g) which is chromatographed on 60 g of alumina eluting with an EP/EA (95/5) mixture. In this way, a white solid is obtained (1.2 g, 40%).

1. temperatureunder reflux for 20 hours
2. customAfter the usual treatment, a brown oil is obtained (1.7 g) which
3. customis chromatographed on 60 g of alumina eluting with an EP/EA (95/5) mixture
4. customIn this way, a white solid is obtained (1.2 g, 40%)