4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

HRID 1251392Notes

Reaction equation

HRID 1251392 reaction equation
[BrH]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:9]([O:11][CH2:12][CH3:13])=[O:10].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1>>[CH2:12]([O:11][C:9](=[O:10])[CH:2]([S:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:13]

Participants

2

Reactant 1

HCID 127654-Methoxybenzenethiol

Product 1

HCID 114383212-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

Procedure

2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from ethyl 2-bromocanate (11.8 g, 47.3 mmol) and 4-methoxythiophenol (6 g, 43 mmol). Yield: 7.24 g (57%); clear oil; MS: 311.2 (M+H)+.

Sources & evidence

ORD record
ord-66dae0abb22f48c987e3bba2fb7a60ec
Source dataset
uspto-grants-2002_01
Patent number
US06342508B1

Reaction notes

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