MeOH tetrahydrofuran → HCID 11048042, compound

HRID 1251456Notes

Reaction equation

HRID 1251456 reaction equation
C([O:3][C:4]([C:6]1([S:21]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH2:11][CH2:10][N:9](OCCC2C=CC=CC=2)[CH2:8][CH2:7]1)=[O:5])C.[CH2:32]1[CH2:36][O:35][CH2:34][CH2:33]1.CO>[OH-].[Na+]>[CH3:31][O:30][C:27]1[CH:26]=[CH:25][C:24]([S:21]([C:6]2([C:4]([OH:3])=[O:5])[CH2:7][CH2:8][N:9]([CH2:32][CH2:36][O:35][C:34]3[CH:33]=[CH:8][CH:7]=[CH:6][CH:4]=3)[CH2:10][CH2:11]2)(=[O:22])=[O:23])=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 21899815MeOH tetrahydrofuranHCID 54484182HCID 54484182, compound

Product 1

HCID 11048042HCID 11048042, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-(4-methoxy-benzenesulfonyl)-1-(2-phenoxy-ethyl)-piperidine-4-carboxylic acid was prepared staring from 4-(4-methoxy-benzenesulfonyl)-1-(2-phenyl-ethoxy)-piperidine-4-carboxylic acid ethyl ester (5.0 g, 11.1 mmol) dissolved in THF:methanol 3:1 and 10 N NaOH (40 ml). The resulting reaction mixture was worked up as outlined in example 83. Yield 3.0 g (63%); off white powder; mp 235° C.; MS: 420.5 (M+H)+.

Workup

  1. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-eba6f5bca21e4d359acd86fa96418c70
Source dataset
uspto-grants-2002_01
Patent number
US06342508B1

Reaction notes

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